Article Title: Association Of Lipid Profile With Depressive Features In Young Hypertensives
Author(s): Ravi Gupta, Ram Kumar Solanki, Vaibhav Dubey, Purav Kumar Midha, Vijay Pathak
Institute(s): Department of Psychiatry, SMS Medical College, JLN Marg, Jaipur, India; Sleep and Headache Care, 1061, Kissan Marg, Barkat Nagar, Jaipur, India; Department of Cardiology, SMS Medical College, JLN Marg, Jaipur, India.
Journal: Journal of Pakistan Psychiatric Society, 2008, Vol. 5, No. 2, p. 101-104
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Objectives: To find out (a) the correlation of various components of serum lipids with depression score; (b) whether severity of depression differ between the people with normal serum lipids & dyslipidemia; and (c) whether the lipid components differ between depressed and non-depressed people.
Design: Cross Sectional Cohort study.
Place and duration of the study: This study was conducted at Sawai Man Singh Medical College and Hospital, Jaipur, India from January 2001 to June 2002.
Subjects and Methods: 100 young primary hypertensive subjects were included in this study. Their fasting blood lipid profile was ascertained and their depressive feelings were rated with the help of HAM-D.
Results: In this study, total lipids, high density lipoprotein, low density lipoprotein, very low density lipoproteins and triglycerides were positively correlated with the HAM D score. Depressed subjects (HAMD>17) had higher levels of total lipids (P=0.002), HDL (P=0.04), VLDL (P=0.02) and TG (P=0.001). Similarly subjects with higher cholesterol levels (P=0.05), normal HDL (P=0.003), normal LDL (P<0.001); higher VLDL (P=0.002) and higher TGs (P<0.001) had higher scores on HAM-D.
Conclusions: This study suggests that low HDL, high LDL protects from the depression. On the other hand, high cholesterol, VLDL and TG increase the risk of depression.
Key words: Hypertension, Young, Lipid profile, Depressive features.